Table 5.

c-KIT and PDGFR inhibitors, target and main clinical indications or trials.

Name (Code) Trade Name	Targets	Approved Clinical Indications or Clinical Trial Study
Imatinib (STI-571) Glivec	PDGFR, c-Kit, v-Abl	GIST, CML (Chronic Myeloid Leukemia), ALL (Acute lymphocytic leukemia), dermatofibrosarcoma protuberans, myelodisplasic síndrome, leukemias.
Avapritinib (BLU-285) Ayvakit	PDGFR, c-Kit	GIST
Ripretinib (DCC-2618) Qinlock	c-Kit, PDGFR	GIST
Amuvatinib (MP-470)	c-Kit, PDGFR, Flt3	Under development in NSCLC (NCT01357395) and other solid tumors (NCT00894894)
Dasatinib (BMS-354825) Sprycel	c-Kit, Abl, Src	CML