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. 2020 Nov 15;21(22):8612. doi: 10.3390/ijms21228612

Figure 3.

Figure 3

Sacubitril/valsartan (SAC/VAL) in a “multi-targeted” therapeutic strategy for COVID-19. SAC/VAL could have potential relevant synergistic effects with most of drugs commonly used in COVID-19 patients, thereby more efficiently fighting the organ injury induced by SARS-CoV-2 infection. Sign “+” indicates pharmacological associations with potential synergistic effects. NPs: natriuretic peptides; BK: bradykinin; SP: substance P; ADM: adrenomedullin; ARBs: angiotensin receptor blockers; ARDS: acute respiratory distress syndrome.