Table 1.
Commercially available 3D in vitro skin models.
| Skin Model | Features | Functions (Tests) | Longevity (Days) |
Supplier | References |
|---|---|---|---|---|---|
| Labskin | Polymerized fibrin dermal equivalent, air exposed and well- differentiated epidermis | Studies interaction between skin and its microbiome, antimicrobial testing, etc. | 10–14 | Innoven Ltd.,York, England UK | [141,145] |
| Episkin™ | Composed of collagen lattice with human fibroblast, surface overlay of human differential epidermis (type IV collagen) | Toxicological assessment of chemicals and products, skin corrosion, etc. | 14 | SkinEthic Labs., Lyon, France | [146] |
| EpiDermFT™ | Full-thickness model with keratin 5, keratin 10 and involucrin, mitotically- and metabolically-active layers, dry surface | Wound healing, skin hydration, anti-aging | 14 | MatTek Life Sciences, Ashland, MA, USA | [147] |
| MelanoDerm™ | Human-derived epidermal keratinocyte and melanocyte, highly differentiated epidermis | Skin pigmentation, lighting efficacy of cosmetic formulations | 14 | MatTek Life Sciences, Ashland, MA, USA | [147] |
| Phenion™ FT LONG-LIFE skin model | Human skin fibroblast and keratinocyte from single donor, full-thickness skin model (3 mm) | Toxicological assessment of chemicals and products, wound healing, skin permeability, drug delivery, etc. | 50 | Henkel AG CO., Dusseldorf, Germany | [142] |