Figure 5.

Schematic representation of the operating mechanism of enzyme-responsive antimicrobial nanosystems consisting of layer-by-layer (LBL)coated MSNs loaded with amoxicillin (AMO). Adapted from ref. [78]. Lysozyme (LYS) was electrostatically adsorbed onto AMO-loaded carboxylate-modified MSNs and then, sequential coating with hyaluronic acid (HA) and 1,2-ethanediamine-modified polyglycerol methacrylate (EDA-PGMA) was carried out. The presence of hyaluronidase enzyme secreted by bacteria triggers cleavage of the capping layer and allows the release of LYS and AMO, with synergistic antibacterial effect.