Table 4.

Haplotype analyses for the NPRL3 and MPG polymorphisms in ischemic stroke patients and controls.

Haplotypes	Controls (2n = 834)	Stroke (2n = 1038)	OR (95% CI)	P	P *
NPRL3 rs2541618 C>T/NPRL3 rs75187722 G>A/MPG rs2562162 C>T/MPG rs710079 C>T
C-G-C-C	418 (50.1)	525 (50.6)	1.000 (reference)
C-A-C-C	21 (2.6)	10 (1.0)	0.379 (0.177–0.814)	0.010	0.129
C-A-T-T	4 (0.4)	0 (0.0)	0.088 (0.005–1.649)	0.039	0.254
T-A-C-C	2 (0.3)	10 (1.0)	3.981 (0.867–18.270)	0.077	0.335
NPRL3 rs2541618 C>T/NPRL3 rs75187722 G>A/MPG rs2562162 C>T
C-G-C	469 (56.2)	568 (54.7)	1.000 (reference)
C-A-T	9 (1.1)	4 (0.4)	0.367 (0.112–1.200)	0.098	0.196
T-G-T	162 (19.5)	243 (23.4)	1.239 (0.981–1.564)	0.072	0.196
T-A-C	0 (0.0)	7 (0.6)	12.390 (0.705–217.600)	0.019	0.112
NPRL3 rs2541618 C>T/NPRL3 rs75187722 G>A/MPG rs710079 C>T
C-G-C	446 (53.5)	568 (54.7)	1.000 (reference)
C-G-T	56 (6.7)	49 (4.8)	0.687 (0.459–1.028)	0.067	0.133
C-A-C	29 (3.5)	10 (1.0)	0.271 (0.131–0.562)	0.0002	0.001
T-A-C	0 (0.0)	14 (1.4)	22.780 (1.354–383.100)	0.001	0.002
NPRL3 rs2541618 C>T/MPG rs2562162 C>T/MPG rs710079 C>T
C-C-C	440 (52.8)	532 (51.3)	1.000 (reference)
T-T-C	159 (19.1)	237 (22.8)	1.233 (0.972–1.563)	0.084	0.586
NPRL3 rs2541618 C>T/NPRL3 rs75187722 G>A
C-G	502 (60.2)	608 (58.6)	1.000 (reference)
T-A	0 (0.0)	5 (0.5)	9.084 (0.501–164.800)	0.068	0.154
NPRL3 rs2541618 C>T/MPG rs2562162 C>T
C-C	545 (65.4)	642 (61.9)	1.000 (reference)
T-T	162 (19.5)	243 (23.4)	1.273 (1.012–1.602)	0.039	0.116
NPRL3 rs75187722 G>A/MPG rs2562162 C>T
G-C	553 (66.3)	669 (64.5)	1.000 (reference)
G-T	195 (23.4)	284 (27.3)	1.204 (0.972–1.492)	0.090	0.147
A-T	10 (1.2)	5 (0.5)	0.413 (0.140–1.217)	0.098	0.147

OR, odds ratio; 95% CI, 95% confidence interval; NPRL3, nitrogen permease receptor like-3; MPG, N-methylpurine DNA glycosylase. * P-value calculated by false discovery rate test. P-values < 0.05 are shown in bold.