Table 2.

Selected key microRNAs (miRNAs) and their reported effects in brite (beige or brown-in-white) adipose tissue.

miRNA	Function(s)	Target(s) *	Reference(s) and Corresponding Study Model(s)
MiR-196a	Plays a role in browning of white progenitor cells, inducing WAT browning and involved in regulating human body fat distribution	Hoxc8	[78]: Mouse; in vitro
MiR-26	Key regulator of human white and beige adipocyte differentiation and positive regulator of brown adipogenesis	ADAM17, Fbxl19	[123]: Human; in vitro [124]: Mouse; in vitro
MiR-125	Negative regulator of browning and the formation of functional brite adipocytes	MMP11	[125]: Human; in vitro
MiR-Let7i-5p	Thermogenesis inhibitor, strongly inhibiting mitochondrial and browning markers in mice scWAT and human and murine brite adipocytes	Not specified	[126]: Human; mouse; in vitro
MiR-455	Positive regulator of brown/beige AT	Ucp1, Runx1t1, Necdin, Hif1an, Tgfbr3	[90]: Human; mouse; in vitro [91]: In vitro [92]: Mouse
MiR-30b/c	Positive regulator of brown and brite adipogenesis	Rip140	[93]: Mouse; in vitro [94]: In vitro
MiR-34a	Negative regulator of brown and brite adipogenesis, exhibiting increased expression in obesity, disrupts FGF21 signaling in AT and prevents PGC1A activation and browning of WAT	Fgfr1	[95]: Mouse; in vitro
MiR-27b	Inhibitor of brown and beige adipogenesis, downregulated during WAT and brite differentiation	Prmd16, Ppara, Pparg, Creb, Pgc1b, Prohibitin	[96]: In vitro [97]: Mouse; in vitro [98]: In vitro
MiR-378	Negative regulator of brite adipogenesis	Pde1b	[99]: Mouse; in vitro
MiR-133	Negative regulator of brown adipogenesis	Prmd16	[100]: Mouse; in vitro [101]: Mouse; in vitro [102]: In vitro
MiR-155	Negative regulator of brown adipogenesis	C/ebpb	[103]: Mouse; in vitro [104]: Mouse; in vitro [105]: Human, Mouse; in vitro
MiR-32	Positive regulator of brown adipogenesis, promoting thermogenesis and WAT browning	Tob1	[106]: Mouse; in vitro

* All abbreviations are detailed in the list of abbreviations of the manuscript.