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HDAC1 acetylation abolishes deacetylase activity and convers its associated corepressor complex to coactivator complex. (A) Schematic representation of HDAC1 acetylation sites. HDAC2 is not acetylated. Note lysine 432 in HDAC1 corresponds to an arginine in HDAC2. (B) HDAC1 and 2 exist as a homo or heterodimer. Acetylation on HDAC1 represses its deacetylase activity and results in inactive deacetylase dimer. (C) HDAC1 acetylation converse NuRD complex to a coactivator complex.
