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. 2020 Nov 11;21(22):8460. doi: 10.3390/ijms21228460

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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HDAC1 in NuRD complex mediates GATA-1 function. (A) A model for GATA-1 mediated gene activation. GATA-1 is recruited to the target sites and subsequently recruits NuRD complex and p300/CBP coactivators. These coactivators acetylate histones, GATA-1 and HDAC1, resulting in gene activation. (B) A model for GATA-1 mediated gene repression. GATA-1 displaces GATA-2 and recruits the NuRD complex with full deacetylase activity for repression. PIC, Pre Initiation Complex. PCAF, p300/CBP-associated factor.