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. 2020 Nov 11;21(22):8460. doi: 10.3390/ijms21228460

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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HDAC1 dependent dynamic transcription activation and repression at PU.1 promoter. (A) TAF9 can be acetylated by an acetyltransferase and subsequently deacetylated by HDAC1. Non-acetylated TAF9 binds to DPE site and associates with TFIID complex to promote PU.1 gene activation. (B) HDAC1 is acetylated or inactivated by HDACi, causing an inability to deacetylate TAF9. Acetylated TAF9 is displaced from DNA. Acetylated TAF9 also causes the disassembly of the TFIID complex from the promoter, resulting in gene repression.