Table 6.
Problem Behavior Assessment (PBA-s) Apathy Factor by Treatment Group and Study Visit (ITT Population). Apathy behavior is rated for frequency and severity on a scale of 0–4 and the Apathy Factor is calculated as frequency * severity.
| Time Point | Statistic | Placebo (N = 36) |
SRX246 120 mg BID (N = 36) |
SRX246 160 mg BID (N = 34) |
|---|---|---|---|---|
| Visit 2, Baseline | n | 35 | 36 | 34 |
| Mean (SD) | 3.5 (3.91) | 4.0 (4.37) | 3.4 (5.01) | |
| Median | 2.0 | 2.0 | 1.0 | |
| Min, Max 95% CI |
0, 16 (2.1, 4.8) |
0, 12 (2.5, 5.5) |
0, 16 (1.7, 5.2) |
|
| Visit 4, Week 6 | n | 35 | 31 | 33 |
| Mean (SD) | 2.9 (4.38) | 2.9 (3.61) | 3.4 (4.64) | |
| Median | 1.0 | 2.0 | 1.0 | |
| Min, Max 95% CI |
0, 16 (1.4, 4.4) |
0, 12 (1.6, 4.2) |
0, 16 (1.7, 5.0) |
|
| Visit 7, End of Treatment | n | 34 | 31 | 33 |
| Mean (SD) | 3.0 (4.17) | 3.4 (4.27) | 3.8 (4.77) | |
| Median | 1.0 | 2.0 | 2.0 | |
| Min, Max 95% CI |
0, 16 (1.5, 4.5) |
0, 16 (1.8, 5.0) |
0, 16 (2.1, 5.0) |