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The potential MC3R mechanisms leading to increase food intake and motivation for highly palatable food (HPF) in preclinical studies. ↓: decrease; ↑: increase; ARC: Arcuate nucleus of the hypothalamus; HPF: Highly palatable food; MC3R: Melanocortin-3 receptor; NPY: neuropeptide Y; POMC: Pro-opiomelanocortin; VTA: Ventral Tegmental Area.
