Table 2.

MC4R variant rs17782313 and manifestation of altered eating behavioral phenotype.

Subjects with the MC4R Variant rs17782313	Result	Ref.
Normal weight vs. obese children of both sexes	Obese children present high scores of Enjoyment of Food, Emotional Overeating, Food Responsiveness and lower Satiety Responsiveness	[17]
Adult participants	In both genders high scores of Emotional Eating associated with BMI were found, while only in women the Uncontrolled Eating scores were associated with BMI.	[20]
Healthy adult volunteers	Only women, especially homozygous carriers of MC4R variant rs17782313, demonstrated Emotional Eating and Disinhibition of Eating.	[141]
Adult women	Women had significantly higher intake of energy from fat, compared to carbohydrate.	[142]
Children, teenagers and adults	Children and teenagers presented snacking and eating large amounts of food during meals. Adults presented a greater hunger score	[143]
Adults between the ages of 24 and 50 years	Overeating behaviors, Emotional Eating and Food Cravings.	[144]
Overweight or obese participants	Less postprandial satiation symptoms after a fully caloric meal	[147]
Obese children	Low Satiety Responsiveness scores and high scores for the Enjoyment of Food	[148]
Obese, overweight and normal weight children	In obese girls were found significant lower scores of the Satiety Responsiveness and higher scores of the Uncontrolled Eating	[153]
Women	Association with increased BMI and obesity	[160,161,163]
Lean, overweight, and obese children	Association with increased BMI and obesity	[155,159]
Normal weight vs. obese adults	Association with increased BMI and obesity	[156,162]
Normal weight vs. obese adults	Association with increased BMI and obesity and a significant higher intake of energy from fat compared to carbohydrate.	[158]

BMI: Body Mass Index; MC4R: Melanocortin-4 receptor.