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. 2020 Nov 13;12(11):1303. doi: 10.3390/v12111303

Figure 8.

Figure 8

(A) Schematic structure of the HERV-K-derived alternative splice products, Env and Rec, and their effect on the endothelial-mesenchymal transition (EMT)-like process of cancer progression EMT(L). The signal peptide (SP); transmembrane subunit (TM); Splice acceptor (Sa); Splice donor (Sd). (B) Modeling the interaction loop between MITF and LTR5_Hs and Rec in melanoma. MITF binds to LTR5_Hs and drives Rec expression from certain Type 2 proviruses. Rec marks the proliferative stage melanoma cells and, similarly to MITF, inhibits the endothelial-mesenchymal transition (EMT)-like process EMT(L). Depletion of Rec results in MITF downregulation and the failure to maintain the balance between cell proliferation and invasion. For the limitation of the model see the Discussion.