Figure 4.

Interactability of Pla with other Y. pestis proteins. The Pla-centered protein-protein interaction (PPI) network was generated by the Search Tool for the Retrieval of Interacting Genes; STRING (http://string-db.org/. STRING). This later generates a network of associations based on predicted and experimentally-validated information on the interaction partners of a protein of interest [108]. In the corresponding network, the nodes correspond to proteins, whereas the edges show predicted or known functional associations. Seven types of evidence are used to build the corresponding network, where they are indicated by the different colored lines: a green line represents neighborhood evidence; a red line—the presence of fusion evidence; a purple line—experimental evidence; a blue line—co-occurrence evidence; a light blue line—database evidence; a yellow line—text mining evidence; a black line—co-expression evidence [108].