Table 3.

Pairs of spike amino acids proven to co-evolve. For each pair, the position of the involved amino acids and their distances are reported.

Amino Acid 1	Amino Acid 2	Position Amino Acid 1	Position Amino Acid 2	Distance (Å)
121	260	Internal	Internal	12
146	148	External	External	5.4
147	151	External	External	6.8
244	531	External	External	29.1
525	546	External	External	12.9