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Hybrid E/M cells as a transition state of epithelial mesenchymal transition (EMT). E, M and E/M specific markers and characteristics during different transition states. Loss of cellular adherens of E cells allow them to undergo EMT and are released into the blood circulations as circulating tumour cells (CTCs). CTCs were found to exhibit hybrid E/M phenotypes which can transform into M forms and induce metastasis through M-to-E transition (MET) at distant sites.
