Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanisms of chemoresistance in AML. Examples of the heterogeneity of mechanisms causing chemoresistance in adult acute myeloid leukemia: (A) Biology of the disease: constitutive activation of FLT3 leading to hyperproliferation and oncogenic activation of p53 through DNA damage induction. (B) Host factors: allele polymorphism leading to resistance to daunorubicin and cytosine arabinoside (Ara-C) and tumor microenvironment. Images were generated using BioRender.
