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. 2020 Nov 12;21(22):8513. doi: 10.3390/ijms21228513

Figure 1.

Figure 1

LIPUS regulates the polarization of macrophages. LIPUS significantly inhibits the LPS-induced activation of p-JNK and p-p65 in macrophages. At the same time, LIPUS down-regulates the expression of IL-1β and TNF-α mRNA, whereas it up-regulates the expression of IL-10 and Arg-1, in macrophages. LIPUS, low-intensity pulsed ultrasound; IL-1β, interleukin-1β; IL-10, interleukin-10; Arg-1, arginase-1; TNF-α, tumor necrosis factor-α; JNK, c-Jun N-terminal kinase; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; LPS, lipopolysaccharide.