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Tumor promoting function of oncogenic pathways deregulated in CAFs. Scheme recapitulates data presented concerning Wnt, Hippo, TGFβ and MAPK pathways deregulation in MAFs and melanoma cells. Mostly, activation of these pathways in MAFs exerts a pro-tumorigenic effect with the exception of Hippo signaling that trigger a competition between tumor and stroma characterized by a tumor-suppressive function.
