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Schematic illustration of the signaling pathways that can be inhibited by sorafenib and calcium influx. Sorafenib inhibits the mitogen-activated protein kinase pathway following recombinant activated factor (RAF) inhibition, and calcium influx inhibits steroid receptor coactivator (Src)-mediated focal adhesion kinase (FAK), resulting in the inhibition of phosphoinositide 3-kinases (PI3K)/Akt/ mammalian target of rapamycin (mTOR) signaling.
