Table 2.
Representative circRNAs and related signaling pathways in colon cancer
| Circular RNA | Expression | Functions | Downstream targets | References |
|---|---|---|---|---|
| CircPPP1R12A | ↑ | Promotes tumorigenesis, Increases proliferation, migration, invasion | Hippo-YAP | [87] |
| CircPIP5K1A | ↑ | Increases viability, migration, invasion | miR-1273a, Zic-1, CDX-2, IRF-4 | [88] |
| CircCTIC1 | ↑ | Promotes tumorigenesis, self-renewal of stem cells | c-Myc | [89] |
| Circ_0001313 | ↑ | Enhances radioresistance | miR-338-3p | [90] |
| CircRNA_104916 | ↓ | Inhibits tumorigenesis, EMT, migration, invasion, induces apoptosis, controls cell cycle. | Apoptosis pathway, cyclin proteins | [91] |
| CircRNA-ACAP2 | ↑ | Enhances proliferation, migration, invasion | hsa-miR-21-5p, Tiam1 | [92] |