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. 2020 Nov 14;21(22):8589. doi: 10.3390/ijms21228589

Figure 3.

Figure 3

The PPI networks, GO annotations, and KEGG pathway enrichment analysis of identified hub genes of miR-141-3p, miR-181b1-5p, and miR-23b-3p. The PPI networks were created using the STRING online database for the identified hub genes obtained from the Cytoscape plugin MCODE analysis. (A) PPI network of the 10 hub genes in cluster 1; (B) PPI network of the 13 hub genes in cluster 2; p < 1.0 × 10−16 and p < 2.49 × 10−14 for the entire PPI network of modules 1 and 2, respectively; (C) bar plot illustrating the GO annotation and KEGG pathway enrichment analyses for cluster 1 hub genes; (D) bar plot illustrating the GO annotation and KEGG pathway enrichment analysis for cluster 2 hub genes. The blue, red, purple, and green bars represent the enrichment analysis results of KEGG, MF, CC, and BP, respectively.