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Adaptive immune response and systemic immune dysfunction in cancer. Upon engulfing tumor antigens dendritic cells (DCs) migrate to lymph nodes. There they initiate anti-tumor immunity, with the activation of CD8+ T cells. DC dysfunction in cancer hosts leads to inefficient T cell response. DCs can induce tolerance with the differentiation of CD4+ T cells into regulatory T cells. Altered systemic immunity affects immune niches in distant organs.
