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. 2020 Nov 13;21(22):8551. doi: 10.3390/ijms21228551

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Myeloid HIF-1α knockout ameliorated whereas myeloid HIF-2α knockout aggravated colitis. Daily recording of the disease activity index (DAI) value with separate presentation for the different animal strains with and without dextran sodium sulfate (DSS) treatment. Statistical analysis was performed with a 2-way ANOVA (mean values ± SEM; (A): n(C) = 2, n(DSS) = 3; (B): n(C) = 3 (LysM^Cre/Cre Hif-2α^fl/fl)/8 (Hif-2α^fl/fl; LysM^Cre/+ Hif-2^αfl/fl), n(DSS) = 8 (LysM^Cre/Cre Hif-2α^fl/fl)/18 (Hif-2α^fl/fl; LysM^Cre/+ Hif-2α^fl/fl); and (C): n(C) = 7, n(DSS) = 14). *: p < 0.05; ***: p < 0.001.