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. 2020 Nov 13;21(22):8551. doi: 10.3390/ijms21228551

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Myeloid knockout of HIF-2α increased the numbers of T-cells and Treg cells in inflamed colon tissue. Exemplary presentation of CD3- (green, surface staining) and FoxP3- (red, nuclear staining) stained colon tissue sections of (A) Hif-2α^fl/fl, LysM^Cre/+ Hif-2α^fl/fl and LysM^Cre/Cre Hif-2α^fl/fl animals, and (B) Hif-1α^fl/fl × Hif-2α^fl/fl and LysM^Cre/+ Hif-1α^fl/fl × Hif-2α^fl/fl animals with and without DSS treatment. (A,B): n(Control) = 2; n(DSS) = 4 (magnification 200×, scale bar: 100 µm). Marked cells (arrows) are double-positive for CD3 and FoxP3.