Table 2.
Transcriptional regulatory network of NFAT/AP-1/IRF4.
| Gene | Function in T cells | Transcription Factors | CD8 T Cell Differentiation State | RREF |
|---|---|---|---|---|
| IL-2 | Clonal expansion | NFAT/AP-1(c-Jun/c-Fos) complex | Effector | [4,17,18,126,137] |
| INFg | Effector cytokine | NFAT/AP-1(c-Jun/c-Fos) complex | Effector | [12,13] |
| TNFa | Effector cytokine | NFAT/AP-1(c-Jun/ATF2) complex | Effector | [130] |
| Granzyme B | Cytotoxic | NFAT-2 | Effector/CTL | [131] |
| Pdcd1 (PD-1) | Immunoregulatory receptor | NFAT; BATF; NFAT/BATF/IRF4 complex |
Exhaustion | [21,138] |
| Havcr2 (TM3) | Immunoregulatory receptor | NFAT/BATF/IRF4 comlex | Exhaustion | [138] |
| Tbx21 (T-bet) | Lineage-specific TF | Jun/BATF/IRF4 complex | Effector | [6] |
| Tcf7 (TCF1) | Lineage-specificTF; self-renewal | Repressed by Blmp1 | Memory; Progenitor- exhausted cells |
[139,140] |
| Prdm1 (Blmp1) | Transcritional repressor | Jun/BATF/IRF4 complex | Memory; Exhaustion |
[6] |
| Eomes | Lineage-specific TF | Jun/BATF/IRF4 complex | Memory; Exhaustion |
[6] |
| TOX | TF; chromatin accessibility | NFAT | Exhaustion | [25,31] |
| NR4A | TF; chromatin accessibility | NFAT | Exhaustion | [29,141] |