Table 1.
Demographic data and cerebrospinal fluid concentrations in patients with early-stage Parkinson′s disease.
| Demographics | n | |
|---|---|---|
| Female/male (n) | 26 | 14/12 |
| Age (years) | 26 | 63 ± 13 (41–84) |
| Education (number per Verhage level 1/2/3/4/5/6/7) | 26 | 0/1/1/3/8/5/8 |
| Disease duration (years) | 26 | 2 (1–5) |
| Hoehn and Yahr stage (nr. per stage 1/1.5/2/2.5/3/4/5) | 26 | 2/3/13/8/0/0/0 |
| UPDRS III score | 26 | 22 (6–38) |
| MMSE score | 26 | 29 (23–30) |
| BDI score | 22 | 8 (0–29) |
| BAI score | 22 | 10 (1–21) |
| CSF Biomarker Levels | ||
| t-α-syn (pg/mL) | 21 | 1271 (723–1950) |
| p-α-syn (pg/mL) | 21 | 268 (165–354) |
| p-α-syn/t-α-syn (%) | 21 | 18.9 (8.5–34.7) |
| NfL (pg/mL) | 20 | 858 (307–4948) |
| Amyloid-β42 (ng/L) | 26 | 931 (400−1211) |
| t-tau (ng/L) | 26 | 186.5 (95.0–369.0) |
| p-tau (ng/L) | 26 | 35.5 (20.0–78.0) |
Data are mean ± SD and range or median and range unless specified otherwise. Abbreviations: CSF, cerebrospinal fluid. UPDRS-III, Unified Parkinson′s Disease Rating Scale Part III. MMSE, Mini-Mental State Examination. t-α-syn, total α-synuclein. p-α-syn, phosphorylated α-synuclein. t-tau, total tau. p-tau, phosphorylated tau. NfL, neurofilament light chain. BDI Beck Depression Inventory. BAI, Beck Anxiety Inventory.