Figure 7.

Schematic representation of fatty acid synthesis and Akt-mediated regulation of lipid metabolism via phosphorylation of its targets and SREBP-dependent expression of various proteins (in light blue). Green arrows indicate Akt-dependent activation, black arrows show the metabolic pathway. Abbreviations: acetyl-CoA carboxylase (ACC), ATP-citrate lyase (ACLY), fatty acid (FA), fatty acid synthase (FASN), low density lipoprotein receptor (LDLR) mechanistic target of rapamycin/mammalian target of rapamycin (mTORC1), stearoyl-coenzyme A desaturase 1 (SCD1), Sterol regulatory element binding proteins (SREBP).