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Ube3b-mediated Ppp3cc regulation. In the forebrain-specific Ube3b cKO mouse, cortical and hippocampal neurons exhibit simpler, less arborized dendritic trees. This phenotype is mimicked, once neurons overexpress gamma-subunit of calcineurin, Ppp3cc, ubiquitination substrate of Ube3b. LC, low complexity; CBB, calcineurin B and calmodulin binding. PolyUb chain on position on Ppp3cc is randomly placed on the scheme to depict Ube3b-mediated ubiquitination.
