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. 2020 Nov 16;9(11):402. doi: 10.3390/biology9110402

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The TBX5-Clover/NKX2.5-TagRFP reporter PSC-CM line uncovers four distinct cardiac progenitor subsets [45]. The TBX5-Clover⁺/NKX2.5-TagRFP⁺ (+,+) (top right) and TBX5-Clover⁻/NKX2.5-TagRFP⁺ (+,−) (bottom right) show phenotypic features of presumptive first heart field and second heart field progenitors which give rise primarily to ventricular-like and atrial-like CMs, respectively. The TBX5-Clover⁺/NKX2.5-TagRFP⁻ (+/−) population (top left) resembles epicardial precursors which can then differentiate into epicardial cell and nodal CM lineages. The TBX5-Clover⁻/NKX2.5-TagRFP⁻ (−,−) population (bottom left) represents distinct endothelial lineage progenitors.