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. 2020 Nov 12;21(22):8544. doi: 10.3390/ijms21228544

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Differential regulation of GnRH signaling pathways via GPCR heterodimerization. Heterodimerization between Ci-GnRHR-1 and -4 results in a 10-fold more potent intracellular calcium ion mobilization response to tGnRH-6 compared with the Ci-GnRHR-1 monomer/homodimer. Heterodimerization between Ci-GnRHR-2 and -4 decreases cAMP production by 50% in response to tGnRH-6, 7, and 8 compared with the Ci-GnRHR-1 monomer/homodimer.