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. 2020 Nov 12;12(11):3347. doi: 10.3390/cancers12113347

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Kaplan–Meier estimates of HCC development in ALC patients in each group who had similar residual liver function according to the albumin–bilirubin (ALBI) grade or fibrosis-4 (FIB-4) scores. Risk stratification for HCC development according to serum myostatin levels among patients who were in ALBI grade 1 (A), grade 2 (B), and grade 3 (C) (all p < 0.01 by log-rank test). Risk stratification for HCC development according to serum myostatin levels among patients who had low FIB-4 scores (≤6.46, median value) (D) and high FIB-4 scores (>6.46) (E) (all p < 0.001 by log-rank test). Abbreviations: ALBI, albumin–bilirubin grade; ALC, alcoholic liver cirrhosis; FIB-4, fibrosis-4; HCC, hepatocellular carcinoma.

Kaplan–Meier estimates of HCC development in ALC patients in each group who had similar residual liver function according to the albumin–bilirubin (ALBI) grade or fibrosis-4 (FIB-4) scores. Risk stratification for HCC development according to serum myostatin levels among patients who were in ALBI grade 1 (A), grade 2 (B), and grade 3 (C) (all p < 0.01 by log-rank test). Risk stratification for HCC development according to serum myostatin levels among patients who had low FIB-4 scores (≤6.46, median value) (D) and high FIB-4 scores (>6.46) (E) (all p < 0.001 by log-rank test). Abbreviations: ALBI, albumin–bilirubin grade; ALC, alcoholic liver cirrhosis; FIB-4, fibrosis-4; HCC, hepatocellular carcinoma.