Table 2.
Cox proportional hazards regression analysis for HCC development in total population (n = 1077).
| Variables | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | p-Value a | HR (95% CI) | p-Value a | |
| Age (per year increase) | 1.04 (1.01–1.06) | <0.001 | 1.03 (1.01–1.06) | 0.004 |
| Gender (male vs. female) | 4.05 (1.48–11.07) | 0.006 | 2.79 (1.01–7.75) | 0.04 |
| Body mass index, kg/m2 | 1.08 (1.02–1.13) | 0.006 | 1.05 (0.98–1.12) | 0.12 |
| Diabetes mellitus (yes vs. no) | 1.42 (0.88–2.29) | 0.16 | ||
| AST (per IU/L) | 0.999 (0.996–1.001) | 0.34 | ||
| ALT (per IU/L) | 0.995 (0.988–1.003) | 0.20 | ||
| Total bilirubin (per mg/dL) | 0.97 (0.91–1.04) | 0.39 | ||
| Albumin (per g/dL) | 0.60 (0.43–0.84) | 0.003 | 0.73 (0.50–1.10) | 0.09 |
| Platelets (per × 109/L) | 0.993 (0.989–0.996) | <0.001 | 0.996 (0.992–0.999) | 0.03 |
| INR | 0.99 (0.89–1.11) | 0.90 | ||
| Creatinine (per mg/dL) | 0.90 (0.51–1.56) | 0.69 | ||
| Child–Pugh score | 1.09 (0.99–1.21) | 0.09 | ||
| FIB-4 | 1.01 (0.99–1.03) | 0.18 | ||
| MELD score | 1.02 (0.98–1.10) | 0.37 | ||
| Myostatin (per ng/mL) | 1.24 (1.19–1.30) | <0.001 | 1.18 (1.12–1.24) | <0.001 |
ap-value estimated by Cox proportional hazard regression. Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CI, confidence interval; FIB-4, fibrosis-4; HR, hazard ratio; INR, international normalized ratio for prothrombin time; MELD, model for end-stage liver disease.