Table 1.

Novel medical applications of CoQ₁₀.

Disease	CoQ10 Application	References
Diabetic cardiovascular diseases and diabetic nephropathy	Significant reduction in adverse cardiovascular events	[11,15,16,17,18,19,20,21,22]
Multiple system atrophy	Accurate biomarker for MSA when found in low levels in cerebrospinal fluid	[20,23,24,25,26,27,28,29,30]
Immunological disorders	Significant improvement of the T cell function Reduction of circulating inflammatory markers	[14,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50]
Neuropathies	Neuroprotection via Ca2+ buffering and antioxidant activity	[35,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79]
UVB radiation damage	Treatment of damaged skin	[66,80,81,82,83,84,85]
Heart failure	Supplementation required for improving patient condition	[82,86,87,88,89,90,91,92,93]
Barth syndrome and membrane instability-related diseases	CoQ10-based treatment for Barth syndrome patients Development of cholesterol-free liposome-based drug delivery systems	[94,95,96,97,98,99,100,101,102,103,104,105,106]
Insulin resistance	Increase in insulin sensitivity by scavenging mitochondrial oxidants	[107,108,109,110,111,112,113,114,115]
Fibromyalgia	Pain alleviation	[116,117,118,119,120,121]
Familial hypercholesterolemia and atherosclerosis	Supplementation required for improving patient condition	[122,123,124,125,126]