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. 2020 Nov 13;9(11):2475. doi: 10.3390/cells9112475

Figure 8.

Figure 8

Intra-islet pericapillary and peri-islet (islet-exocrine interface) fibrosis. (Panel (A)) depicts the widening and early peri-capillary fibrosis in the Zucker obese male model of insulin resistance, obesity and impaired glucose tolerance at 12 weeks of age. (Panels (B,C)) demonstrate the close association of the islet-exocrine interface, with only slight widening at even high magnification between the exocrine and endocrine pancreas in the male control Sprague–Dawley control (SDC) model at 10 weeks of age. (Panels (E,F)) demonstrate a marked widening at higher magnification as compared to the SDC model in B and C in addition to the accumulation of collagen (X). Importantly, (Panel (D)) depicts the extrusion of collagen from a pancreatic stellate cell (PSC) in the Ren2 model at 10 weeks of age; scale bar = 200 nm. IEI = islet-exocrine interface; ISG = islet secretory granule; M and m = mitochondria; PSC = pancreatic stellate cell; RBC = red blood cell; rER = rough endoplasmic reticulum; X = collagen within the widened IEI.