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. 2020 Aug 18;58(6):1118–1129. doi: 10.1093/ejcts/ezaa205

Table 5:

Studies that did not use an omental pedicled flap method

First author Year MI model in vivo Coronary artery for MI Intervention interval after MI Subjects (n)/group Bioengineered cardiac tissue Method utilizing omentum Mode of tissue delivery
Bourahla et al. [31] 2010 Sheep
  • LAD (distal)

  • D2

3 weeks 10 Omental cells or skeletal myoblast cells Isolation and expansion of autologous omental mesothelial cells Injection into MI area
De Siena et al. [32] 2010 Pig LAD 45 min 13 Human fat omentum-derived stromal cells Isolation and expansion of human fat omentum-derived stromal cells Injection into proximal MI border zone
Dvir et al. [33] 2009 Rat LAD 1 week 11 Alginate-based cardiac patch containing neonatal cardiac cells and pro-survival and angiogenic factors (stromal cell-derived factor-1, IGF-1, VEGF) Cardiac patch was vascularized on the omentum Transplantation onto MI area

D2: second diagonal coronary artery; IGF-1: insulin-like growth factor 1; LAD: left anterior descending coronary artery; MI: myocardial infarction; VEGF: vascular endothelial growth factor.