Table 5:
First author | Year | MI model in vivo | Coronary artery for MI | Intervention interval after MI | Subjects (n)/group | Bioengineered cardiac tissue | Method utilizing omentum | Mode of tissue delivery |
---|---|---|---|---|---|---|---|---|
Bourahla et al. [31] | 2010 | Sheep |
|
3 weeks | 10 | Omental cells or skeletal myoblast cells | Isolation and expansion of autologous omental mesothelial cells | Injection into MI area |
De Siena et al. [32] | 2010 | Pig | LAD | 45 min | 13 | Human fat omentum-derived stromal cells | Isolation and expansion of human fat omentum-derived stromal cells | Injection into proximal MI border zone |
Dvir et al. [33] | 2009 | Rat | LAD | 1 week | 11 | Alginate-based cardiac patch containing neonatal cardiac cells and pro-survival and angiogenic factors (stromal cell-derived factor-1, IGF-1, VEGF) | Cardiac patch was vascularized on the omentum | Transplantation onto MI area |
D2: second diagonal coronary artery; IGF-1: insulin-like growth factor 1; LAD: left anterior descending coronary artery; MI: myocardial infarction; VEGF: vascular endothelial growth factor.