Table 2.

Cox regression analysis of the association between mitotic and proliferative biomarkers and progression-free survival in 24 malignant meningioma patients.

Overall Staining in Relation to PFS	No. of Patients	HR (95% CI)	p-Value
Mitoses in 10 HPF (MI)	24	1.08 (1.01–1.15)	0.0221 *
PHH3 mitoses in 10 HPF (PHH3 MI)	24	1.09 (1.03–1.15)	0.0032 *
Ki-67 overall expression < 10%	9	1.00
Ki-67 overall expression > 10%	15	5.40 (1.79–16.27)	0.0028 *
Hot Spot Staining in Relation to PFS	No. of Patients	HR (95% CI)	p-Value
Max. no. mitoses in 1 HPF	24	1.61 (1.12–2.31)	0.0103 *
Max. no. PHH3 mitoses in 1 HPF	24	1.59 (1.15–2.21)	0.0056 *
Max. no. Ki-67 positive nuclei/100 nuclei	24	1.06 (1.02–1.11)	0.0040 *

The consensus data from observers A and B were used for the analyses. All analyses were adjusted for age. * p < 0.05.