Table 2.

Most used immunohistochemical markers for brain metastasis.

Squamous Cell K.	CK5/6, CK7, EMA, GFAP
Small cells K of the lung	CD56, CK7, TTF1, EMA
Lung Adeno-K	CK7, TTF1, Napsin A, EMA, CAM 5.2, CEA, RCC (Variable)
Breast Adeno-K	CK5/6 (Variable), CAM 5.2, CK7, GCDFP15, EMA, S100 (variable), CEA, CA 15-3
Endometrial K	CAM 5.2, CK7, CA 125, ER (variable), CA125, CEA
Colorectal Adeno-K	CAM 5.2, CK20, CDX2, EMA, CEA, CA 19.9
Stomach Adeno-K	CAM 5.2, CK7, CK20, CDX2, EMA, CEA, CA 19.9
Prostate Adeno-K	PSA, EMA
Urothelial K	CK5/6, CK7, CK20, EMA
Renal cell K	RCC, EMA, PAX8, Vimentin
Melanoma	Vimentin, Melan A, S100, HMB 45

K = carcinoma; Adeno-K= adenocarcinoma; CK = cytokeratin; EMA = epithelial membrane antigen; TTF1 = Thyroid transcription factor 1; PSA = prostate-specific antigen; RCC = renal cell carcinoma protein; CEA = Carcinoembryonic antigen; CA = carbohydrate antigen.