Table 4.
Summary of the drug/compound libraries used in the antifungal drug repurposing (see also Table S1, Supplementary Materials).
| Drug, Compound Libraries | Sources | Fungi Tested | References |
|---|---|---|---|
| MDL Drug Data Report (MDDR), DrugBank, TargetMol databases or library (L4200) |
BIOVIA and Thomson Reuters https://www.drugbank.ca/, http://targetmol.com/ |
C. albicans, Paracoccidioides species |
[20,167] |
| Prestwick Chemical Library |
Prestwick Chemical (Illkirch, France) http://www.prestwickchemical.com/ |
Candida species, Cryptococcus species, Saccharomyces cerevisiae, Aspergillus fumigatus, Fusarium oxysporum, Fusarium solani, Lichtheimia species, Lomentospora prolificans, Paecilomyces variotii, Rhizopus arrhizus, Scedosporium apiospermum |
[23,25,66,75,83,94,96,124,165,228] |
| Pharmakon1600 drug library | MicroSource Discovery Systems (Gaylordsville, CT, USA) http://www.msdiscovery.com/ |
C. albicans,
C. glabrata C. auris |
[68,77,162] |
| Library of Pharmacologically Active Compounds (LOPAC1280) | Sigma-Aldrich (St. Louis, MO, USA) https://www.sigmaaldrich.com/ |
Exserohilum rostratum | [101] |
| Medicines for Malaria Venture (MMV) Malaria Box | Medicines for Malaria Venture (Geneva, Switzerland) https://www.mmv.org/ [229] |
C. albicans, C. gatti, C. neoformans, L. prolificans, Fonsecaea pedrosoi, Fonsecaea monophora, Fonsecaea nubica, Cladophialophora carrionii, Phialophora verrucosa, Rhinocladiela similis, Exophiala jeanselmei var. heteromorpha, Exophiala dermatitidis |
[91,148] |
| Screen-Well Enzo library of 640 compounds |
Enzo Life Sciences (Farmingdale, NY, USA) https://www.enzolifesciences.com/ |
Aspergillus species, Candida, Cryptococcus deuterogattii, Saccharomyces |
[110] |
| L1300 Selleck library, 1018 United States Food and Drug Administration (FDA)-approved Selleck library |
Selleck Chemicals https://www.selleckchem.com/ |
A. fumigatus,
C. gattii, C. glabrata, C. neoformans, Trichophyton rubrum |
[73,100] |
| Pathogen Box® chemical library | Medicines for Malaria Venture (Geneva, Switzerland) https://www.mmv.org/ |
C. auris | [119] |
| United States National Institutes of Health/National Cancer Institute (NIH/NCI) compound library |
Developmental Therapeutics Program of the NIH/NCI (Rockville, MD, USA) https://dtp.cancer.gov/ |
A. fumigatus, Candida species, C. neoformans |
[127] |
| 1547 or 1581 FDA-approved drug library |
Johns Hopkins, USA Johns Hopkins Clinical Compound Library (JHCCL) version 1.0 |
C. albicans,
C. auris, C. krusei, C. parapsilosis, C. tropicalis |
[133,163] |
| 678 Maybridge collection | Thermo Fisher Scientific (Waltham, MA, USA) https://www.thermofisher.com/us/en/home/chemicals/maybridge.html |
C. albicans,
C. auris |
[169] |