Figure 2.

The effect of the exposome on innate immunity. (A) The order of exposure to external stimuli can have an important effect on innate immunity. (B) These stimuli elicit various epigenetic and metabolic changes that in turn dictate (C) lineage commitment and the strength of the innate immune response, which ultimately determine (D) the health outcome of the affected individual. The blue and orange lines in (C) denote innate immunity activation (blue line) versus tolerization (orange line).