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The proven and possible training effects of Bacillus Calmette–Guerin (BCG) vaccination. While BCG vaccination results in increased protection against a variety of pathogens due to trained immunity in both mice and humans (dark green boxes), the severity of multiple other diseases and pathologies is known to be abrogated by BCG vaccination, but this may be due to either innate trained immunity or lymphocyte-mediated heterologous effects (light green boxes).
