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. 2020 Nov 13;12(11):3356. doi: 10.3390/cancers12113356

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Serum IL-10, CCL22, and CCL26 levels are linked with overall survival. Groups were divided into cytokine high and low populations using the median cytokine level as a cut-off and OS was visualized using Kaplan–Meier curves. Elevated IL-10 was associated with a shorter OS time (a), whereas elevated levels of CCL22 (b) and CCL26 (c) were associated with longer OS time. Combining cohorts of patients with favorable cytokine conditions also showed a survival advantage, e.g., for CCL22^hi/IL-10^lo (d) CCL26^hi/IL-10^lo (e) and CCL22^hi/CCL26^hi cohorts (f). Log-rank (Mantel–Cox) tests were performed to assess median survival time differences between groups and data were visualized using Kaplan–Meier curves. OS = Overall Survival, IL = Interleukin.

Serum IL-10, CCL22, and CCL26 levels are linked with overall survival. Groups were divided into cytokine high and low populations using the median cytokine level as a cut-off and OS was visualized using Kaplan–Meier curves. Elevated IL-10 was associated with a shorter OS time (a), whereas elevated levels of CCL22 (b) and CCL26 (c) were associated with longer OS time. Combining cohorts of patients with favorable cytokine conditions also showed a survival advantage, e.g., for CCL22^hi/IL-10^lo (d) CCL26^hi/IL-10^lo (e) and CCL22^hi/CCL26^hi cohorts (f). Log-rank (Mantel–Cox) tests were performed to assess median survival time differences between groups and data were visualized using Kaplan–Meier curves. OS = Overall Survival, IL = Interleukin.