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The function of cyclin-dependent kinase (CDK) 20 (CDK20) and p21Cip1/Waf1 in cell cycle regulation. CDK20 plays a positive regulation on cell cycles by activating CDK2 and cyclin D, while p21Cip1/Waf1 acts as a cell cycle inhibitor to arrest cell cycle by binding to CDK2, CDK4/6, CDK1, cyclins, and proliferating cell nuclear antigen (PCNA).
