Table 3.
C-indexes, c-indexes comparison, integrated discrimination improvement (IDI), and net reclassification improvement (NRI) after the addition of miRNAs to the 2MACE score.
| C-index | 95% CI | Z Score * | p * | IDI | 95% CI | p | NRI | 95% CI | p | |
|---|---|---|---|---|---|---|---|---|---|---|
| 2MACE | 0.694 | 0.617–0.764 | ||||||||
| + miR-107 + miR-146a-5p | 0.759 | 0.686–0.822 | 2.876 | 0.004 | 0.053 | 0.011/0.096 | 0.014 | 0.345 | −0.327/0.518 | 0.736 |
| + miR-107 + miR-146a-5p+ miR-22-3p | 0.762 | 0.689–0.825 | 2.518 | 0.012 | 0.056 | 0.012/0.101 | 0.015 | 0.047 | −0.274/0.519 | 0.627 |
* for C-index comparison. CI = confidence interval; IDI = integrated discrimination improvement; NRI = net reclassification improvement.