Figure 11.

Acetylation on MnSOD is associated to inactivation of its biological function. MnSOD acetylation is intimately linked to inactivation of MnSOD enzymatic function either 14 days (A) and 21 days (B) post injury. In fact, when compared with sham group, CCI rats showed low levels of MnSOD activity. Subcutaneous infusion of BPF (50 mg/kg), concurrently with surgery (day 0), prevented mitochondrial proteins acetylation. Results are expressed as mean ± SEM for 6 rats. * p < 0.05 versus sham; ^† p < 0.05 versus vehicle + CCI.