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. 2020 Nov 16;12(11):3389. doi: 10.3390/cancers12113389

Figure 2.

Figure 2

The role of DNA-PKcs in cancer progression. (A) Violin plots showing the association between PRKDC expression and histological grades of TCGA tumors. Note that the information on the histological grades is only available for several cancer types. (B) Correlation analysis of the epithelial-to-mesenchymal transition (EMT; left) and stemness (right) signatures and gene expression of PRKDC across the TCGA pan-solid cancer cohort. Curated EMT [34,35] and mRNA-based stemness scores [36] derived by the stemness group was used. ACC, adrenocortical carcinoma; BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, cholangiocarcinoma; COAD, colon adenocarcinoma; ESCA, esophageal carcinoma; GBM, glioblastoma multiforme; HNSC, head and neck squamous cell carcinoma; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; KIRP, kidney renal papillary cell carcinoma; LGG, brain lower grade glioma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; MESO, mesothelioma; OV, ovarian serous cystadenocarcinoma; PAAD, pancreatic adenocarcinoma; PCPG, pheochromocytoma and paraganglioma; PRAD, prostate adenocarcinoma; READ, rectum adenocarcinoma; SARC, sarcoma; SKCM, skin cutaneous melanoma; STAD, stomach adenocarcinoma; TGCT, testicular germ cell tumors; THCA, thyroid carcinoma; UCS, uterine carcinosarcoma; UCEC, uterine corpus endometrial carcinoma; UVM, uveal melanoma. The detailed information about the bioinformatic analysis can be found in the Supplementary Material.