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Key stromal signals in PDA. myCAFs (blue) respond to HH and TGF-β ligands secreted by tumor cells (purple), express high levels of αSMA, and restrict tumor growth. iCAFs (red) are maintained by tumor-derived IL1α and TNFα, express IL6, and promote tumor growth. apCAFs (teal) express MHC Class II and can present antigens to T cells.
