Table 4.
Cut-off points for combined sensitivity and specificity with the best score (Youden’s test) on the qSOFA and SOFA for two-day mortality.
| Scores | Statistics | All Patients 1 | Non-Infectious Pathology 1 | Infectious Pathology 1 |
|---|---|---|---|---|
| Prevalence | 0.084 | 0.084 | 0.082 | |
| qSOFA | Cut-off | 2 | 2 | 2 |
| Se | 84.9 (75.0–91.4) | 82.8 (71.1–90.4) | 93.3 (70.2–98.8) | |
| Sp% | 69.4 (66.1–72.5) | 69.8 (66.1–73.3) | 67.7 (60.2–74.3) | |
| PPV | 20.3 (16.1–25.1) | 20.2 (15.6–25.7) | 20.6 (12.7–31.6) | |
| NPV | 98.0 (96.5–98.9) | 97.8 (96.0–98.8) | 99.1 (95.2–99.8) | |
| LR(+) | 2.77 (2.41–3.20) | 2.74 (2.32–3.24) | 2.89 (2.23–3.74) | |
| LR(−) | 0.22 (0.13–0.38) | 0.25 (0.14–0.44) | 0.10 (0.01–0.66) | |
| OR | 12.77 (6.61–24.68) | 11.12 (5.51–22.43) | 29.30 (3.75–228.61) | |
| DA | 70.7 (67.6–73.6) | 70.9 (67.4–74.2) | 69.8 (62.8–76.0) | |
| SOFA | Cut-off | 4 | 3 | 6 |
| Se | 87.7 (78.2–93.4) | 96.6 (88.3–99.0) | 86.7 (62.1–96.3) | |
| Sp% | 80.7 (77.4–83.3) | 73.0 (69.4–76.3) | 88.0 (82.2–92.1) | |
| PPV | 29.4 (23.7–35.7) | 24.8 (19.6–30.8) | 39.4 (24.7–56.3) | |
| NPV | 98.6 (97.4–99.3) | 99.6 (98.4–99.9) | 98.7 (95.2–99.6) | |
| LR(+) | 4.54 (3.84–5.36) | 3.58 (3.12–4.10) | 7.24 (4.58–11.42) | |
| LR(−) | 0.15 (0.08–0.28) | 0.05 (0.01–0.18) | 0.15 (0.04–0.55) | |
| OR | 29.69 (14.46–60.97) | 75.76 (18.29–313.88) | 47.78 (10.04–227.42) | |
| DA | 81.3 (78.5–83.7) | 75.0 (71.6–78.1) | 87.9 (82.4–91.9) |
1 Bracketed numbers indicate 95% confidence interval. Se: sensitivity; Sp: specificity; PPV: positive predictive value: NPV: negative predictive value; LR: likelihood ratio; OR: odds ratio; DA: diagnostic accuracy; qSOFA: quick sequential organ failure assessment score; SOFA: sequential organ failure assessment score.