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. 2020 Nov 10;25(22):5234. doi: 10.3390/molecules25225234

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Fendiline hydrochloride treatment induces NDM29 expression and downregulates ABC transporters in neuroblastoma (NB) cells. (A) Effect of fendiline (0.01, 0.1, 1, 25, and 50 μM) on wild type SHSY5Y cell viability. Dose-response curves were obtained from cell index measured by the xCELLigence system. Cell index was recorded every 30 min and results for each concentration were the average of three replicates. Red line: untreated cells (DMSO); green line: 0.01 μM Fendiline; blue line: 0.1 μM fendiline; pink line: 1 μM fendiline; cyan line: 25 μM fendiline; purple line: 50 μM fendiline. (B) Expression levels of NDM29 in SHSY5Y cells either treated or untreated with fendiline (0.01, 0.1, and 1 μM), and measured by real-time RT-PCR. Values are reported as the mean ± SD. ** indicates p ≤ 0.01; two-tailed Student’s t test was applied.