Table 4.

The table summarizes in vivo studies that evaluate the effects of SFN in PD. In particular, we described the models utilized, the dosage, the type of administration, and the results.

Experimental Models	Dose/Concentration Range	Route of Administration	Results	References
C57Bl/6 mice	SFN (5 mg/kg)	Intraperitoneal	SFN administration improved motor deficits and protected the neurons from neurodegeneration and apoptosis	[93]
C57Bl/6 mice	SFN (50 mg/kg)	Intraperitoneal	SFN treatment prevented the motor deficits and loss of dopaminergic neurons. Moreover, SFN reduced oxidative stress	[94]
C57Bl/6 mice	0.1% glucoraphanin pellet	Oral	The treatment with 0.1% glucoraphanin pellet preserved the dopaminergic neurons from the neurodegeneration	[95]
Wild-type mice and Nrf2-KO mice	SFN (50 mg/kg)	Intraperitoneal	In wild-type mice, SFN acting through Nrf2 attenuated both nigrostriatal neurodegeneration and neuroinflammation	[96]

SFN: sulforaphane; Nrf2: nuclear factor erythroid 2 related factor 2; KO: knockout.